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We report significant heterogeneities in ECG metric values that are attributed to methodological differences (e.g., ECG lead configuration, ECG recording platform, presence or absence of anesthesia) that persist even within the same cohort of animals.
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Awake limb lead ECG recordings were collected in vivo from adult guinea pigs using a platform ECG system, while recordings in anesthetized animals were performed using both a platform and needle ECG system. In this study, we investigated variables that are likely to influence ECG metric measurements in cardiovascular research, including recording technique, use of anesthesia, and animal model characteristics. 4Department of Pediatrics, Washington D.C., DC, United StatesĮlectrocardiograms (ECG) are universally used to measure the electrical activity of the heart however, variations in recording techniques and/or subject demographics can affect ECG interpretation.3Department of Pharmacology & Physiology, Washington D.C., DC, United States.2Children’s National Heart Institute, Washington D.C., DC, United States.1Sheikh Zayed Institute for Pediatric Surgical Innovation, Washington D.C., DC, United States.Swift 1,2 and Nikki Gillum Posnack 1,2,3,4* Cooper 1,2,3, Fiona Berk 1, Anysja Roberts 1,2, Luther M.